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Abstract #0189

Preliminary Application of in vivo Cardiac Diffusion Weighted MRI at 3T in Chronic Myocardial Infarction Porcine Model

Christopher Nguyen 1,2 , Yibin Xie 1,2 , Zhaoyang Fan 1 , Behzad Sharif 1 , James Dawkins 3 , Eleni Tseliou 3 , Xiaoming Bi 4 , Rohan Dharmakumar 1 , Eduardo Marban 3 , and Debiao Li 1,2

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 3 Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4 MR R&D, Siemens Healthcare, Los Angeles, CA, United States

Using a chronic myocardial infarction (MI) pig model, we demonstrated that motion compensated cardiac diffusion-prepared turbo-spin echo was able to reveal statistically significant increases (~50%) in trace apparent diffusion coefficient (trADC) in late gadolinium enhanced (LGE)-defined chronic MI regions. Because the infarcted region is akinetic, bulk motion corruption would have resulted in a decrease in trADC, which is opposite to the expected and reported increase in trADC. Furthermore, the agreement in trADC-defined MI location and area with LGE-defined MI regions suggests that the proposed technique delineated infarct tissue. This may potentially allow for non-contrast tissue characterization of chronic MI.

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