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Abstract #0197

Anthranilic Acid Analogues as Uncommonly Shifted HYdrogen bonded (U SHY) diamagnetic CEST (diaCEST) MRI Contrast Agents based on the N-H exchange

Xiaolei Song 1,2 , Xing Yang 1 , Sangeeta Ray Banerjee 1 , Martin G Pomper 1,3 , and Michael T McMahon 1,2

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 3 Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, Maryland, United States

Diamagnetic chemical exchange saturation transfer (diaCEST) agents form a new class of imaging agents with unique magnetic resonance properties. Here we present a series of anthranilic acid analogues as examples of Uncommonly Shifted HYdrogen-bonded (U SHY) diaCEST agents, which produce significant and tunable contrast between 4.8 - 9.3 ppm from water. Five of these analogues, N-sulfonyl anthranilic acids, are highly soluble and produce strong CEST contrast. We also discovered that flufenamic acid, a commercial non-steroidal anti-inflammatory drug, displays CEST contrast at 4.8 ppm. These N-H U SHY agents, with contrast insensitive to pH, are complementary to existing diaCEST probes.

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