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Abstract #0207

Analysis and Optimization of Quantitative Magnetization Transfer Imaging Considering the Effect of Non-Exchanging Component

Pouria Mossahebi 1 , Andrew L Alexander 2,3 , Aaron S Field 1,4 , and Alexey A Samsonov 4

1 Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 2 Medical Physics, University of Wisconsin, Madison, WI, United States, 3 Waisman Lab for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States, 4 Radiology, University of Wisconsin, Madison, WI, United States

Gray matter demyelination has recently been recognized as an important pathological substrate of MS disease. MT imaging approaches has demonstrated high sensitivity to myelination in white matter. Its applications to cortical GM characterization, however, we have to take into account additional factors related to anatomical organization of cortical GM such as partial volume effect (PVE) with CSF. We have proposed a qMT imaging (NE-mCRI) approach that allows isolating a non-exchanging (NE) voxel compartment with distinct relaxation properties such as CSF. In this work, we analyze the effect of NE component on MTR and mCRI parameters and provide results of numerical, phantom and in-vivo validation of the approach as a way to minimize underestimation of qMT measures due to PVE. Additionally, we developed a fast-optimized protocol for in-vivo application of NE-mCRI.

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