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Abstract #0210

Quantitative magnetization transfer imaging of rodent glioma using selective inversion recovery

Junzhong Xu 1 , Ke Li 1 , Zhongliang Zu 1 , Xia Li 1 , Dainel F Gochberg 1 , and John C Gore 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States

This study demonstrates the first implementation of quantitative MT imaging of cancer using selective inversion recovery. In addition, a new SIR-EPI sequence was developed to accelerate the acquisition but retain the fitting accuracy of qMT parameters. The results presented not only assist better understanding of the changes in the macromolecular contents of tumors, but also are important for quantifying other imaging contrasts such as chemical exchange saturation transfer (CEST) of tumors.

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