Differentiation of white-matter differences across sub-clinical psychotic experiences using diffusion tensor and quantitative relaxometry imaging
Mark Drakesmith 1 , Anirban Dutt 2 , Glyn Lewis 3 , Anthony S David 2 , and Derek K Jones 1
CUBRIC, Cardiff University, Cardiff, Wales,
of Psychiatry, Kings College London, London, United
Unit of Psychiatry, University of Bristol, Bristol,
Few studies have examined white-matter correlates of
psychotic experiences in an at-risk population. We show
using DTI and quantitative T1 white-matter differences
associated with sub-clinical psychotic experiences.
Individuals with psychotic experiences show reduced FA,
AD and increased RD in left medial frontal white matter.
No differences in T1 were identified. A number of
variables, especially auditory hallucinations,
negatively correlate with FA, globally. Some variables
also negatively correlate with T1, suggesting a positive
correlation with myelination. Future identification of
subjects who transition to full psychosis will enable
isolation of more specific white-matter predictors of
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