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Abstract #0237

Effects of Age and Smoking on Endothelial Function Assessed by Quantitative MRI in the Peripheral and Central Vasculature

Yongxia Zhou 1 , Michael C Langham 1 , Erica N Chirico 1,2 , Erin K Englund 1 , Emile R Mohler III 3 , Jeremy F Magland 1 , Wensheng Guo 4 , and Felix W Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 School of Nursing, University of Pennsylvania, Philadelphia, PA, United States, 3 Medicine, University of Pennsylvania, Philadelphia, PA, United States, 4 Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States

The purpose was to assess various surrogates of endothelial dysfunction using parameters derived from dynamic MRI sequences. Measures of peripheral vascular reactivity were assessed via dynamic venous oximetry, arterial hyperemia and multi-segment pulse-wave velocity (PWV) of thoracic and abdominal aorta in the form of a single, integrated MR protocol in 132 subjects consisting of young and old smokers and nonsmokers. Our results demonstrate significant aging and smoking effects based on parameters determined from dynamic MRI measures, thereby providing new vascular biomarkers for the effect of age and smoking on vascular endothelial function.

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