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Abstract #0254

Discrete Wavelet Analysis of Longitudinal Resting State fMRI in Mild TBI Patients

Chandler Sours 1,2 , Haoxing Chen 3 , Steven Roys 1 , and Rao P. Gullapalli 1,2

1 Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States, 2 Magnetic Resonance Research Center (MRRC), Baltimore, MD, United States, 3 University of Maryland School of Medicine, Baltimore, Maryland, United States

We investigated the mechanisms of recovery following mild traumatic brain injury (mTBI) using discrete wavelet analysis of resting state fMRI and its relationship with post concussive syndrome (PCS). Our results demonstrate reduced strength of resting state coherence within the Default Mode Network in mTBI with PCS compared to those without PCS within multiple frequency ranges. These findings stress the importance of investigating resting state coherence using discrete wavelet analysis: however, further research is needed incorporating cardiac and respiratory monitoring as well as a sliding window analysis to fully characterize the dynamic properties of resting state coherence in mTBI patients.

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