Neural mechanisms of brain plasticity with cognitive training in healthy seniors
Sina Aslan 1,2 , Sandra B Chapman 2 , Jeffrey S Spence 2 , Molly Keebler 2 , Nyaz Didehbani 2 , and Hanzhang Lu 3
Advance MRI, LLC, Frisco, Texas, United
for BrainHealth, University of Texas at Dallas, Dallas,
Texas, United States,
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
This study investigates that engaging in complex mental
activity offer promising ways to enhance brain integrity
to promote successful cognitive aging. Using three
MRI-based measurements, i.e. pCASL MRI, fcMRI, and DTI,
we examined brain changes across three time points pre,
mid, and post-training (12-weeks) in a randomized sample
who received cognitive training versus a control group.
We found significant training-related brain state
changes at rest; specifically, (1) increases in global
and regional CBF, particularly in the default mode and
central executive networks, (2) greater connectivity in
these same networks, and (3) increased white matter
integrity in the left uncinate fasciculus.
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