Application of compressed-sensing-accelerated diffusion spectrum imaging in patients with brain tumors
Ek T Tan 1 , Robert J Young 2 , Kyung K Peck 2,3 , Xiaofeng Liu 1 , Jonathan I Sperl 4 , Mehrnaz Jenabi 2 , and Luca Marinelli 1
GE Global Research, Niskayuna, NY, United
Memorial Sloan Kettering Cancer Center, New York, NY,
Physics, Memorial Sloan Kettering Cancer Center, New
York, NY, United States,
Global Research, Garching, Munich, Germany
Compressed-sensing accelerated diffusion spectrum
imaging (CS-DSI) was compared to conventional DTI in ten
patients with intracranial brain tumors, whereby DSI
clearly provides improved performance in the presence of
crossing-fibers and (edema and tumors). DSI acquisition
was accelerated by factors of 4 and 5 to achieve scan
times under 14 minutes on a conventional 3T system.
CS-DSI provided superior tract visualization in all
patients. The tract-based dependent measures obtained
with CS-DSI were more consistent with pathology-induced
changes than those with DTI. These preliminary results
suggest that CS-DSI may be helpful in preoperative
planning in patients with brain tumors.
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