Diurnal Variation of Portal Hemodynamics with 4D flow MRI
Alejandro Roldn-Alzate 1 , Camilo A Campo 1 , Kevin M Johnson 2 , Oliver Wieben 1 , and Scott B Reeder 1
Radiology, University of Wisconsin, Madison,
Wisconsin, United States,
Physics, University of Wisconsin, Madison, Wisconsin,
The purpose of this study was to evaluate diurnal
changes in mesenteric blood flow in normal subjects and
patients with portal hypertension using 4D-flow-MRI.
Three patients and seven controls were studied. A total
of 5 4D-flow-MRI acquisitions were performed along the
day to mimic potential imaging schedules. Healthy
controls revealed larger changes in blood flow than
those in portal hypertension patients. Reduced
hemodynamic response in patients may be due to
structural and functional vascular changes resulting
from cirrhosis. A comprehensive characterization of
portal hypertension hemodynamics using 4D-flow MRI would
provide valuable information for stratification of
variceal bleeding risk in patients.
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