Abstract #0376
Frame-by-Frame 1H MRS for In Vivo Pancreatic Fat Quantification
Qing Yuan 1 , Daniella F Pinho 1 , Ivan E Dimitrov 2,3 , Ivan Pedrosa 1,2 , Yin Xi 1 , Ildiko Lingvay 4 , Anna Vanderheiden 4 , and Robert E Lenkinski 1,2
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States,
3
Philips
Medical Systems, Cleveland, OH, United States,
4
Internal
Medicine, UT Southwestern Medical Center, Dallas, TX,
United States
Accurate pancreatic fat quantification using 1H MRS in
humans is challenging due to the fact that the pancreas
is surrounded by visceral fat, and it moves with
respiration. In this study, frame-by-frame acquisition
with different respiratory compensation methods was
performed. Single frame spectrum analysis shows large
variation of fat fraction regardless of the respiratory
compensation method utilized. Our results indicate that
frame-by-frame acquisition is crucial for 1H MRS of
pancreas in vivo. Using the minimum fat fraction from
all frames may be a more reliable method when measuring
pancreatic fat content.
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