Intravoxel Incoherent Motion MR Imaging shows lower pure molecular diffusion, lower diffusion fraction linked to microcirculation, and lower perfusion-related diffusion in fibrotic livers with a severity correlated manner
Yi-Xiang Wang 1 , Pu-Xuan Lu 2 , Hua Huang 2 , Feng Zhao 1 , and Jing Yuan 1
Dept Imaging and Interventional Radiology,
The Chinese University of Hong Kong, Shatin, NT, Hong
of Radiology, the Shenzhen Third People's Hospital,
Shenzhen, Guangdong, China
This current study reports the results of intravoxel
incoherent motion (IVIM)-based diffusion weighted
imaging evaluation of 17 healthy volunteers and 34 liver
fibrosis subjects. Pure molecular diffusion (D), the
fraction of the diffusion linked to microcirculation
(f), and perfusion-related diffusion (D*) were computed.
The results demonstrated all D value, f value, and D*
value were significantly lower in the fibrosis livers
compared with the healthy livers, and progressively
lower as the severity of liver fibrosis increased.
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