Abstract #0420
Velocity-Selective Inversion Prepared Arterial Spin Labeling for 3D Whole-Brain Perfusion Measurment
Qin Qin 1,2 and Peter C.M. van Zijl 1,2
1
Radiology, Johns Hopkins University,
Baltimore, Maryland, United States,
2
Kirby
Center, Kennedy Krieger Institute, Baltimore, Maryland,
United States
A novel velocity-selective inversion pulse preparation
is developed based on the k-space formalism, which is
robust to B0/B1 inhomogeneity and eddy currents by
embedding a pair of adiabatic pulses for refocusing in
each k-segment. This new pulse, dubbed Double-Refocused
Inversion with Velocity Encoding (DRIVE), is applied to
velocity-selective Arterial Spin Labeling (VSASL) for
cerebral blood flow (CBF) measurement at 3T. We
performed VSASL using the DRIVE pulse train and a
standard Pseudo-Continuous ASL (PCASL) with 3D
whole-brain acquisition for comparison. The results show
excellent agreement between the two methods in both CBF
quantification and SNR level.
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