Abstract #0454
Multiparametric functional MRI for assessment of delayed renal allograft function
Dagmar Hartung 1,2 , Marcel Gutberlet 1,2 , Frank Lehner 2,3 , Nicolas Richter 3 , Nils Hanke 4 , Jan Becker 2,5 , Matti Peperhove 1 , Antonia Zapf 6 , Hermann Haller 4 , Frank Wacker 1 , Wilfried Gwinner 2,4 , and Katja Hueper 1,2
1
Radiology, Hannover Medical School,
Hannover, Germany,
2
Integrated
Research and Treatment Center Transplantation (IFB Tx),
Hannover, Germany,
3
Transplantation Surgery,
Hannover Medical School, Hannover, Germany,
4
Nephrology,
Hannover Medical School, Hannover, Germany,
5
Pathology,
Hannover Medical School, Hannover, Germany,
6
Medical
Statistics, University Goettingen, Goettingen, Germany
Delayed renal allograft function (DGF) is associated
with an increased risk of graft complications. We
investigated whether multiparametric functional MRI
allows evaluation of DGF. Fourty patients between day
4-10 after kidney transplantation were examined using a
1.5T-scanner. Renal perfusion, apparent diffusion
coefficients and fractional anisotropy were
significantly reduced in patients with DGF compared to
patients with normal initial graft function.
Furthermore, functional MRI parameters were inversely
correlated with serum creatinine at the day of MRI and
at 3-months follow-up. Thus, multiparametric functional
MRI may improve non-invasive diagnosis of DGF.
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