Diffusion characteristic of infused Acetate in the rat brain in vivo
Masoumeh Dehghani M. 1 , Bernard Lanz 1 , Nicolas Kunz 2 , Corina Mihaela Berset 2 , and Rolf Gruetter 1,3
Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne,
Lausanne, Vaud, Switzerland,
for Biomedical Imaging, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Vaud, Switzerland,
of Radiology, Universities of Lausanne and Geneva,
Lausanne and Geneva, Switzerland
The aim of this study is to address the diffusion
characteristic of Acetate(Ace) in the rat brain in vivo
using localized diffusion weighed STEAM-based
spectroscopic pulse sequence. The study design is based
on the assumption that intracellular and extracellular
metabolites experiences different diffusion behavior.
Minimizing GABA peak contribution at 1.89 ppm in 1H MR
spectra improved the accuracy of the measurement of Ace
time course and the Ace diffusion in brain in vivo. The
significantly larger ADC of Ace compared to
intracellular metabolites suggests a substantial Ace
concentration in the extracellular space of rat brain
during Ace infusion.
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