Meeting Banner
Abstract #0472

Exploring the inherent CEST MRI signal of anticancer drug gemcitabine

Yuguo Li 1,2 , Kannie Chan 1,2 , peter van Zijl 1,2 , Bert Vogelstein 3 , Michael McMahon 1,2 , Shibin Zhou 3 , and Guanshu Liu 1,2

1 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 FM Kirby center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Ludwig Center, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Non-invasive tracking of drug delivery is of great clinical interest. Herein, we explored a direct way to track liposome mediated delivery of gemcitabine, a first-line drug for treating pancreatic cancer. We show that this can be achieved using its inherent Chemical Exchange Saturation Transfer (CEST) MRI signal at 2.1 and 1.0 ppm originating from the exchangeable amino and hydroxyl protons, respectively. Unlike traditional approaches, the CEST MRI detection doesnt require the use of extra contrast agents, and is able to directly convert the gemcitabine-loaded nanoparticle drug delivery system into a theranostic system.

This abstract and the presentation materials are available to members only; a login is required.

Join Here