Abstract #0478
Regional variations of GABA, glutamate, glutamine and NAAG in the human brain, as measured by 1H MRS at 7T in vivo
Changho Choi 1 , Sandeep Ganji 1 , Zhongxu An 1 , and Akshay Madan 1
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, Texas, United
States
We report regional variations in metabolite levels in
healthy human brain, focusing on GABA, glutamate,
glutamine, and N-acetyl-aspartyl-glutamate. A
GABA-tailored PRESS sequence (TE = 92 ms) was used, at
7T, to measure the metabolites in gray matter (GM) and
white matter (WM) dominant regions in the frontal and
occipital brain in 9 healthy volunteers. Metabolite
levels in pure GM and WM were obtained with linear
regression of metabolite estimates vs. fractional GM
contents. The result indicated that the concentrations
of many metabolites are significantly different between
frontal and occipital brain as well as between GM and
WM.
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