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Abstract #0482

1H-MRS study in investigating the effect of dioscorea modified pill to the cognitive impairment of patients with VCIND

Jun Chen 1 , Jinhuan Liu 1 , Zihu Tan 2 , Qiong Yang 2 , Hanchao Lan 2 , Yilin Zhao 1 , Dongjie Huang 1 , Qizhong Xu 1 , and Liang Zhang 1

1 Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China, 2 Department of Geriatrics, Hubei Hospital of Traditional Chinese Medicine, Wuhan, Hubei Province, China

Vascular Cognitive Impairment No Dementia (VCIND) is introduced to identify the earliest stage of cognitive decline associated with vascular disease, which does not meet dementia criteria but with an increased risk of death and institutionalization1. Early detection of VCIND has significant clinical implications for a valid prognosis and treatement2. Proton magnetic resonance spectroscopy (1H-MRS) has been proved useful in investigating neurodegenerative diseases3. In this study, the therapeutic effect of Dioscorea modified pill and Aricept to VCIND patients was evaluated using brain 1H-MRS, mini-mental state examination (MMSE), clinical dementia rating (CDR) and Montreal Cognitive Assessment (MoCA) simultaneously and the relationship of these measurements was investigated as well.

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