Neuropathologic correlates of regional brain volumes assessed with ex-vivo MRI.
Aikaterini Kotrotsou 1 , David A. Bennett 2 , Julie A. Schneider 2 , Sue E. Leurgans 2 , Tom Golak 1 , and Konstantinos Arfanakis 1,2
Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, Illinois,
Alzheimer's Disease Center, Rush University Medical
Center, Chicago, Illinois, United States
Brain atrophy is considered a biomarker of Alzheimer's
disease (AD) pathology. However, mixed pathologies are
common in the elderly, and several of them may lead to
atrophy. Also, only a handful of studies with low
numbers of participants have combined brain MR volumetry
with measures of neuropathology obtained after death.
Thus, the relation between brain atrophy and age-related
neuropathology is actually not well-established. The
purpose of this investigation was to assess the
neuropathologic correlates of regional brain volumes by
combining ex-vivo MR volumetry and pathology information
on a large community cohort of older persons.
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