New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates
Matthias Vandesquille 1,2 , Tengfei Li 2,3 , Chrystelle Po 1 , Christelle Ganneau 2 , Christian Czech 4 , Charles Duyckaerts 3 , Benot Delatour 3 , Sylvie Bay 2 , Pierre Lafaye 2 , and Marc Dhenain 1
MIRCen, CEA, Fontenay-aux-Roses, France,
Pasteur, Paris, France,
Hpital de la Piti-Salptrire, Paris, France,
Roche, Basel, Switzerland
Amyloid deposits occur many years before
neuropsychological symptoms of Alzheimer's disease.
Their detection by MRI is thus critical. We designed a
contrast agent combining the properties of VHH
antibodies and gadolinium to specifically label amyloid
plaques by MRI. We showed that hypointense spots were
observed on T2* images following
injection of the VHH-DOTA/Gd. Several spots were
colocalized with the amyloid plaques revealed by a
reference (Gold-standard) Gd-staining procedure.
Overall, this study describes a new promising tool for
the detection of amyloid deposits by MRI.
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