Abstract #0507
Linkage of vertebral bone marrow fat content with biomechanical strength and trabecular bone structure parameters
Thomas Baum 1 , Stefan Ruschke 1 , Olga Gordijenko 1 , Eduardo Grande Garcia 1 , Hendrik Kooijman 2 , Rainer Burgkart 3 , Ernst J Rummeny 1 , Jan S Bauer 4 , and Dimitrios C Karampinos 1
1
Department of Radiology, Klinikum
rechts der Isar, Technische Universitt Mnchen,
Munich, Bavaria, Germany,
2
Philips
Healthcare, Hamburg, Hamburg, Germany,
3
Department
of Orthopedics and Orthopedic Sports Medicine,
Technische Universitt Mnchen, Munich, Bavaria,
Germany,
4
Department of Neuroradiology,
Klinikum rechts der Isar, Technische Universitt
Mnchen, Munich, Bavaria, Germany
There is a growing interest in understanding the
linkage between bone marrow adiposity and bone
weakening. The present pilot ex vivo study
investigates, using human spine specimens, the
relationship between MRS-based vertebral bone
marrow proton density fat fraction, MDCT-based
measures of BMD and trabecular microstructure,
and biomechanical strength. The reported results
confirm the previously reported negative
association between bone marrow fat content and
bone mineral density and provide the first
direct validation of a negative association
between bone marrow fat content and bone
biomechanical strength.
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