Predicting Whole Bone Strength in Radii Using MRI Measurements of Bound and Pore Water
Mary Kate Manhard 1,2 , Sasidhar Uppuganti 3 , Mathilde C Granke 3 , Jeffry S Nyman 3 , and Mark D Does 1,2
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
University Institute of Imaging Science,
Vanderbilt University, Nashville, TN, United
of Orthopaedics & Rehab, Vanderbilt University,
Nashville, TN, United States
Ultra-short echo time (UTE) measures of bound
and pore water using the DAFP and AIR sequences
were found in cortical bone of the radius in
cadaveric specimens. The concentrations of bound
and pore water were correlated to mechanical
properties found from a three-point bend test.
DXA and μCT imaging measures on the same bones
were also correlated to mechanical properties.
Bound and pore water correlated well with
bending strength, while DXA and μCT showed
slightly weaker correlations. Additionally,
bound water was significantly correlated with
toughness. These results validate the potential
for MRI as a useful tool for predicting fracture
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