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Abstract #0516

Comprehensive Hemodynamic Evaluation of Intracranial Atherosclerotic Disease with 4D Flow MR Imaging

Can Wu 1 , Shyam Prabhakaran 2 , Timothy Carroll 1,3 , Parmede Vakil 3 , Neil Chatterjee 1,3 , Amir Honarmand 3,4 , Sameer Ansari 3,4 , James Carr 3 , and Michael Markl 1,3

1 Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2 Neurology, Northwestern University, Chicago, IL, United States, 3 Radiology, Northwestern University, Chicago, IL, United States, 4 Neurological Surgery, Northwestern University, Chicago, IL, United States

The purpose of this study was to evaluate the feasibility of 4D flow MR imaging for the comprehensive evaluation of intracranial hemodynamics in 20 patients with intracranial atherosclerotic disease (ICAD) including quantitative analysis of peak velocity and mean blood flow in the large intracranial vessels. The results demonstrated significant impact of regional stenotic lesions on the hemodynamics in systemic vascular territories. Combined evaluation of the qualitative visualization of the blood flow patterns and distribution of blood flow velocities and quantitative hemodynamic markers may provide additional insight into the pathophysiology and risk stratification for ICAD patients.

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