Abstract #0538
Fat Compostion Determination via Combined 13 C and 1 H MRS at Ultra High Field
Sergey Cheshkov 1,2 , Ivan Dimitrov 1,3 , Karlos Moreno 1 , and Craig Malloy 1,2
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Radiology,
University of Texas Southwestern Medical Center, Dallas,
TX, United States,
3
Philips
Medical Systems, Cleaveland, OH, United States
Studies indicate that composition of body adipose
tissue, which is sensitive to diet, may predispose to
cancer. Utilizing the increased chemical shift
dispersion, proton MRS at 7T has been used as a
non-invasive tool for fat composition determination in
human calf muscle and breast. Compared to proton MRS,
13
C
with its large chemical shifts provides significant
advantage in measuring multiple additional lipid
fractions. In this work we investigate a combined
13
C
and
1
H
MRS benefiting from the high specificity of
13
C
and high signal to noise of
1
H
spectrum for ultimately more reliable lipid composition
determination.
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