Abstract #0563
Clinical Effectiveness of Three Noninvasive Methods for Detecting Hepatic Fibrosis
Jun Chen 1 , Meng Yin 1 , Jennifer Oudry 2 , Jayant Talwalkar 1 , Kevin Glaser 1 , Thomas Smyrk 1 , and Richard Ehman 1
1
Mayo Clinic, Rochester, MN, United States,
2
Echosens,
Paris, France
Since liver biopsy -the reference method- has some
significant limitations for detecting hepatic fibrosis,
noninvasive technologies have been developed, such as MR
Elastography (MRE), Fibroscan and FIBROSpect II. The
purpose of this study was to evaluate the clinical
effectiveness of these three methods in a single patient
population with a consideration for interobserver
variations of liver pathology. ROC analysis shows a
diagnostic accuracy (>= F2) of 90.7%, 88.9% and 83.0%
for MRE, FIBROSpect II and Fibroscan, respectively. MRE
has the highest negative predictive value (90.0%),
indicating patients without clinically significant
fibrosis could be diagnosed by MRE and avoid liver
biopsy.
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