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Abstract #0567

Pontine Hyperintensities are a Sensitive Indicator of Small Vessel Disease in Elderly Patients with Dementia

Owen Thomas 1 , Ammar Issa 2 , Thomas P Hansen 2 , John Cain 2 , Nitin Purandare 3 , and Alan Jackson 2

1 Department of Neuroradiology, Salford Royal NHS Hospitals Foundation Trust, Manchester, Lancashire, United Kingdom, 2 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, Lancashire, United Kingdom, 3 Greater Manchester Old Age Psychiatry Service, University of Manchester, Manchester, Lancashire, United Kingdom

We examine the discriminative power of brainstem hyperintensities in an elderly population of patients with vascular dementia (VaD), Alzheimers dementia (AD) and age-matched normal controls. Hyperintensities in the pons were scored using a novel system and combined with scores of hyperintensity in the hemispheric white-matter, dilated perivascular spaces, lacunar and hemispheric infarcts. The presence of pontine and medial lemniscus hyperintensities provided the greatest independent discriminative power for the separation of VaD and AD accounting for 40% and 12% of the variance in the linear regression model respectively. The area under the receiver operator curve was 0.833.

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