Optogenetic control of hemodynamic response in rat somatosensory cortex - fMRI and optical study
Bistra Iordanova 1 , Alberto T Vazquez 1 , Alex Poplawsky 1 , Takashi Kozai 2 , Hiro Fukuda 1 , Matthew Murphy 1 , and Seong-Gi Kim 1,3
Dept. of Radiology, University of
Pittsburgh, Pittsburgh, PA, United States,
of Bioengineering, University of Pittsburgh, Pittsburgh,
PA, United States,
of Biological Sciences, Center for Neuroscience Imaging
Research, Suwon, Korea
We use optogenetic approach to modulate the activity of
the pyramidal cells in the primary somatosensory cortex.
We record hemoglobin-based optical intrinsic signal
(OIS) at different light activation parameters. We then
compare the OIS to blood oxygenated level dependent
(BOLD) fMRI activation.
This abstract and the presentation materials are available to members only;
a login is required.