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Abstract #0582

Distinct BOLD fMRI Responses of Capsaicin-induced Thermal Sensation Reveal Pain-related Brain Activation in Non-Human Primate

Abu Bakar Ali Asad 1 , Stephanie Seah 1 , Richard Baumgartner 2 , Dai Feng 2 , Andres Jensen 1 , Brian Henry 1 , Andrea Houghton 3 , Jeffrey Evelhoch 4 , and Chih-Liang Chin 1

1 Translational Medicine Research Centre, MSD, Singapore, Singapore, 2 Biometrics Research, Biostatistics and Research Decision Sciences, Merck & Co Inc, Rahway, New Jersey, United States, 3 Neuroscience, Merck & Co Inc, West Point, Pennsylvania, United States, 4 Imaging, Merck & Co Inc, West Point, Pennsylvania, United States

To bridge preclinical research and clinical investigation, we established a capsaicin pain heat fMRI model in non-human primate with heat/42 C stimuli. We hypothesize potentiation in heat-induced cortical activation in response to capsaicin application at the forearm will highlight the pain matrix depicted in human pain fMRI experiments. Our results indicate that group comparisons of brain activation between pre- and post-capsaicin application show significant increases in BOLD signals at the frontal, cingulate, precentral and postcentral gyrus, and cerebellum (paired t-test, p<0.002, n=8). Our data provide insights into differentiating brain regions involved with pain-like responses or thermal sensation.

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