Which parameters are optimal? - A comprehensive numerical analysis of background phase correction with SHARP
Ferdinand Schweser 1 , Pιnar Senay zbay 2,3 , Andreas Deistung 1 , Edsel Daniel Peres Gomez 1 , Xiang Feng 1 , Daniel Nanz 2 , and Jrgen R Reichenbach 1
Medical Physics Group, Institute of
Diagnostic and Interventional Radiology I, Jena
University Hospital - Friedrich Schiller University
Jena, Jena, Germany,
of Radiology, University Hospital Zurich, Zurich,
for Biomedical Engineering, University and ETH Zurich,
Sophisticated harmonic artifact reduction for phase data
(SHARP) is regarded as one of the most important
techniques in the area of background correction for QSM.
The influence of the SHARP parameters has not been
investigated in detail so far and they are usually
chosen empirically, which may have serious consequences
for the comparability of studies relying on SHARP
processed phase images. We performed a comprehensive
analysis of the impact of different parameter choices on
the resulting images and propose a universal definition
of the regularization parameter that does not depend on
the spherical radius or on the image resolution.
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