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Abstract #0612

Limits of liver fat quantification in the presence of severe iron overload

Diego Hernando 1 , Samir D. Sharma 1 , and Scott B. Reeder 1,2

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Medicine, University of Wisconsin-Madison, Madison, WI, United States

Chemical shift-encoded fat quantification requires the acquisition of images at multiple echo times to enable fat-water separation and R2* estimation. Excessive tissue iron deposition can severely increase R2*, complicating fat quantification. In this work, we assess the feasibility of chemical shift encoded liver fat quantification in the presence of liver iron using theoretical analysis and in vivo patient data. Our results demonstrate that fat quantification fails at high iron levels when using standard protocols. The use of shorter initial echo time and echo spacing significantly extends the range of iron levels over which accurate fat quantification is possible.

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