Magnetic Susceptibility Anisotropy of the Myocardium
Russell Dibb 1,2 , Luke Xie 1,2 , and Chunlei Liu 3,4
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, NC, United States,
Engineering, Duke University, Durham, NC, United States,
Imaging & Analysis Center, Duke University Medical
Center, Durham, NC, United States,
Duke University Medical Center, Durham, NC, United
The magnetic susceptibility of myocardium is anisotropic
and is associated with myocardial organization. We
determined the relationship between the magnetic
susceptibility and the DTI-based fiber orientation of
myocardial tissue. The origins of the observed bulk
magnetic susceptibility anisotropy in myocardium can be
related to the microscopic anisotropy of peptide bonds
in myofibrillar proteins. In MRI, this susceptibility
anisotropy is enhanced by the use of contrast agents.
Given the high-resolution capability of gradient echo
phase, imaging susceptibility anisotropy of the heart
would aid in assessing myocardial fiber integrity and
alterations induced by cardiac diseases and disorders.
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