3D Modeling of Spatial Resolution Limitations in Contrast-Enhanced MRA Related to the Contrast Bolus Profile using an Analysis of the Modulation Transfer Function
Jeffrey H. Maki 1 , Toshimasa J. Clark 1 , and Gregory J. Wilson 1
Radiology, University of Washington,
Seattle, WA, United States
Image quality and resolution in CE-MRA depend in part on
the rate, quantity and type of Gd contrast agent
administered. To evaluate different injection
strategies, a physiologic model of bolus delivery from
the antecubital vein to the artery of interest was used
to predict contrast agent concentration vs. time.
Contrast agent relaxivities (T1 and T2*) in oxygenated
whole blood were then used to predict signal intensity
modulation during the CE-MRA acquisition, which
ultimately leads to blurring in CE-MRA. Blurring was
evaluated in image space for varying injections using
modulation transfer function analysis.
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