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Abstract #0652

3D Modeling of Spatial Resolution Limitations in Contrast-Enhanced MRA Related to the Contrast Bolus Profile using an Analysis of the Modulation Transfer Function

Jeffrey H. Maki 1 , Toshimasa J. Clark 1 , and Gregory J. Wilson 1

1 Radiology, University of Washington, Seattle, WA, United States

Image quality and resolution in CE-MRA depend in part on the rate, quantity and type of Gd contrast agent administered. To evaluate different injection strategies, a physiologic model of bolus delivery from the antecubital vein to the artery of interest was used to predict contrast agent concentration vs. time. Contrast agent relaxivities (T1 and T2*) in oxygenated whole blood were then used to predict signal intensity modulation during the CE-MRA acquisition, which ultimately leads to blurring in CE-MRA. Blurring was evaluated in image space for varying injections using modulation transfer function analysis.

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