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Abstract #0673

Convection Enhanced Delivery of Toca 511 into Recurrent GBM Under Real-Time MR Guidance

Alastair Martin 1 , Manish Aghi 2 , Adrian Kells 2 , John Bringas 2 , Paul Larson 2 , Geoffrey Bates 3 , Peter Piferi 3 , Douglas Jolly 4 , Joan Robbins 4 , Derek Ostertag 4 , Carlos Ibanez 4 , Harry Gruber 4 , Krystof Bankiewicz 2 , and Daniel Pertschuk 4

1 Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2 Neurological Surgery, UCSF, CA, United States, 3 MRI Interventions, Irvine, CA, United States, 4 Tocagen, San Diego, CA, United States

Intra-operative MR methods are employed to administer an investigational retroviral replicating vector (vocimagene amiretrorepvec; Toca 511) in a series of 7 patients with GBM. MR targeting is employed to insert a stepped infusion cannula to selected sites within the tumor. The vector is infused via convection enhanced delivery and real-time intra-operative MR monitoring of the infusion process is achieved by mixing the vector with an MR contrast agent. Good volumetric coverage of the tumors was achieved, with minimal extra-tumoral extension or reflux along the cannula tract evident.

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