Modeling the hemodynamic response in stimulus-evoked mouse fMRI
Felix Schlegel 1 , Aileen Schroeter 1 , and Markus Rudin 1,2
Institute for Biomedical Engineering, ETH
and University of Zrich, Zrich, Zrich, Switzerland,
of Pharmacology and Toxicology, University of Zrich,
Zrich, Zrich, Switzerland
For stimulus-evoked fMRI in mice, the standard analysis
tools may not be appropriate as the intrinsic
assumptions of linearity relating stimulus and
hemodynamic response and the use fixed shapes of the
hemodynamic response function (HRF) may not be valid.
Here, we show how the sensitivity and specificity of
BOLD fMRI in mice can be improved by employing
appropriate experimental designs and analysis
approaches. We found that in out data, event-related
designs produce more specific responses than block
designs and that nonlinear regression approaches
outperform traditional methods like finite impulse
responses, SPM basis functions or fixed HRF shapes.
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