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Abstract #0770

Comparison of regional ventilation defect distribution between oxygen-enhanced and hyperpolarized He-3 MRI

Stanley J Kruger 1 , Scott K Nagle 1,2 , Robert V Cadman 1 , Kevin M Johnson 1,2 , Laura C Bell 1 , Andrew D Hahn 1 , and Sean B Fain 1,2

1 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2 Radiology, University of Wisconsin - Madison, Madison, WI, United States

Oxygen Enhanced MRI with 3D radial ultrashort echo time (OE-MRI) is an emerging technique for the evaluation of lung ventilation with advantages over hyperpolarized noble gas MRI (HP-MRI) in terms of accessibility and cost effectiveness. Nonetheless, HP-MRI is an emerging reference standard for pulmonary MRI of ventilation. The purpose of this work is to compare the heterogeneity of ventilation as depicted regionally for the same subjects with HP-MRI and OE-MRI to evaluate regional distribution of ventilation defects using the respective techniques. The whole-lung coverage provided by 3D radial OE-MRI could be readily compared to HP-MRI as a reference standard.

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