Abstract #0776
Using Hyperpolarized 129 Xe MRI to Quantify Differences in Regional Ventilation in Older Versus Younger Asthmatics
Mu He 1 , Suryanarayanan Sivaram Kaushik 1,2 , Scott Haile Robertson 1,3 , Matthew S Freeman 1,3 , Rohan S Virgincar 1,2 , Holman Page McAdams 4 , Denise Beaver 5 , Monica Kraft 5 , and Bastiaan Driehuys 1,2
1
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, NC, United States,
2
Department
of Biomedical Engineering, Duke University, Durham, NC,
United States,
3
Medical
Physics Graduate Program, Duke University, Durham, NC,
United States,
4
Department
of Radiology, Duke University Medical Center, Durham,
NC, United States,
5
Department
of Pulmonary and Critical Care Medicine, Duke University
Medical Center, Durham, NC, United States
Asthma treatment is generally less effective for older
patients. Yet, most published studies exclude subjects
aged over 65 years-of-age to avoid expected confounding
effects from other coexisting obstructive lung
disorders. In this work, hyperpolarized
129
Xe
MRI was used to acquire ventilation images in younger
and older asthmatics, as well as healthy controls
matched for body mass, ethnicity, and age. To quantify
differences between groups, test for short-term image
reproducibility and evaluate bronchodilator response, we
introduce an improved semi-automated cluster analysis
method to calculate ventilation defect percentage (VDP).
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