Abstract #0779
Probing Lung Microstructure with Gradient Echo Plural Contrast Imaging
Alexander L Sukstanskii 1 , James D Quirk 1 , and Dmitriy A Yablonskiy 1
1
Radiology, Washington University, St. Louis,
Missouri, United States
A new approach Gradient Echo Plural Contrast Imaging (GEPCI)
of lungs is proposed for simultaneously extracting
information about lung ventilation, alveolar parameters
and blood vessel network structure from a single
multi-gradient-echo experiment. Based on computer
simulations of 3He atoms diffusion in the acinar airway
tree in the presence of inhomogeneous magnetic field
induced by the susceptibility differences between lung
tissue (alveolar septa, blood vessels) and lung
airspaces, we derive analytical expressions relating the
time-dependent MR signal to the geometrical parameters
of acinar airways and blood vessel network. Data
obtained on 8 healthy volunteers are in good agreement
with literature values.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
