Abstract #0791
The impact of gradient strength on in vivo diffusion MRI estimates of axon diameter
Susie Y. Huang 1 , Aapo Nummenmaa 1 , Thomas Witzel 1 , Tanguy Duval 2 , Julien Cohen-Adad 2 , Lawrence L. Wald 1,3 , and Jennifer A. McNab 4
1
Athinoula A. Martinos Center for Biomedical
Imaging, Department of Radiology, Massachusetts General
Hospital, Harvard Medical School, Boston, MA, United
States,
2
Institute
of Biomedical Engineering, Ecole Polytechnique de
Montreal, Montreal, QC, Canada,
3
Harvard-MIT
Division of Health Sciences and Technology,
Massachusetts Institute of Technology, Cambridge, MA,
United States,
4
Richard
M. Lucas Center for Imaging, Department of Radiology,
Stanford University, Stanford, CA, United States
Translating diffusion MRI methods for axon diameter
mapping to clinical applications requires higher maximum
gradient strengths (Gmax) than are currently available
on commercial scanners. Using a dedicated high-gradient
3T MRI scanner with Gmax=300mT/m, we systematically
study the effect of gradient strength on
in
vivo
axon
diameter estimates in the human corpus callosum. We find
that an optimal q-space sampling scheme should
incorporate the highest possible gradient strengths and
draw from a wide range of gradient strengths and
diffusion times. The improvement in axon diameter
estimates will inform protocol development and encourage
the adoption of higher gradient systems for widespread
use.
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