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Abstract #0807

Plasma Metabolomics in Childhood Obesity using 1 H NMR

Hetty Prinsen 1 , Cosimo Giannini 2 , Robin A de Graaf 1 , Nicola Santoro 1 , Christoph Juchem 1 , Sonia Caprio 1 , and Raimund I Herzog 1

1 Yale University, New Haven, CT, United States, 2 University of Chieti, Chieti, Italy

The prevalence of obesity has increased to epidemic levels, not only in adults, but also in children. Obesity has been associated with the development of insulin resistance, progression to type 2 diabetes, development of fatty liver, and progression to liver cirrhosis. We are still in need for sensitive biomarkers that allow identification of the particularly at risk individuals amenable to early and intensive interventions. Here we correlate clinical markers of obesity-related complications with plasma metabolite levels in obese insulin-sensitive and insulin-resistant youth, using a novel workflow for acquisition and processing of metabolomic 1 H NMR data.

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