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Abstract #0814

Measurement of T 2 and T 2 * in Spin Echo Single Point EPR Imaging Using a Single Acquisition Method

Hyungseok Jang 1 , Sankaran Subramanian 2 , Nallathamby Devasahayam 2 , Shingo Matsumoto 2 , Keita Saito 2 , Murali C. Krishna 2 , and Alan B. McMillan 1

1 Radiology, University of Wisconsin, Madison, WI, United States, 2 Radiation Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, United States

Electron paramagnetic resonance imaging (EPRI) has surfaced as a promising technique that can allow quantitative imaging of tissue oxygenation. Owing to the extremely short spin-spin relaxation time, single point imaging (SPI) is used, where entire FID is phase-encoded. Several methods have been proposed to overcome zoom-in effect inherent in SPI-EPRI. Among them, spin echo based SPI-EPRI (ESPI-EPRI) is worthy of study because it can allow simultaneous T 2 and T 2 * estimation when combined with a single acquisition method. In this study, the physical and physiological significance of T 2 and T 2 * measures was explored through the proposed single acquisition method in ESPI-EPRI.

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