Abstract #0829
Mapping the Unidirectional Pi-to-ATP Fluxes in Muscles of the Lower Leg by Using Progressive Saturation 31P-MRI with PCr Suppression at 7.0 T
Prodromos Parasoglou 1 , Ding Xia 1 , and Ravinder R Regatte 1
1
Radiology, NYU School of Medicine,
New York, New York, United States
Phosphorus saturation transfer methods can
assess the turnover rates of important metabolic
reactions such as the adenosine triphosphate
(ATP) synthesis/hydrolysis cycle. In this study,
we focused on the development and implementation
of an imaging method for simultaneously
measuring the kinetics of ATP synthesis and the
Pi-to-ATP fluxes in muscles of the lower leg.
Mapping the kinetics of the ATP synthesis
reaction and the Pi-to-ATP fluxes in several
muscles of the leg using our imaging method
could provide useful insights into the study of
diseases such as insulin resistance and
diabetes.
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