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Abstract #0875

Assessment of diastolic dysfunction in hypertensive patients using full-cycle cine DENSE

Bhairav Bipin Mehta 1 , Sujith Kuruvilla 2 , Michael Salerno 1,2 , and Frederick H Epstein 1,3

1 Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States, 2 Department of Medicine, Cardiology Division, University of Virginia, Charlottesville, Virginia, United States, 3 Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, United States

Diastolic dysfunction is independently associated with increased cardiovascular mortality. Echocardiography is commonly used for assessment of diastolic function. However, echocardiographic techniques have limitations which are not present in strain and strain rate measurement using MRI. We previously developed a full-cycle cine DENSE sequence that can accurately compute systolic and diastolic strains and strain rates. In the present study we compared full-cycle cine DENSE results between hypertensive patients and healthy volunteers. The patients showed significantly reduced peak early diastolic strain rate and increased peak atrial systolic strain rate compared to volunteers, illustrating full-cycle DENSEs ability to assess diastolic dysfunction.

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