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Abstract #0894

Iron accumulation is a rare feature in multiple sclerosis lesions

Vanessa Wiggermann 1,2 , Lisa E. Lee 3 , Enedino Hernndez Torres 1,4 , David K.B. Li 1,4 , Alex L. MacKay 2,4 , Irene M. Vavasour 1,4 , Anthony Traboulsee 4,5 , and Alexander Rauscher 1,4

1 Radiology, University of British Columbia, Vancouver, BC, Canada, 2 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3 Science, University of British Columbia, Vancouver, BC, Canada, 4 UBC MRI Research Centre, Vancouver, BC, Canada, 5 Neurology, University of British Columbia, Vancouver, BC, Canada

The contrast observed in MR frequency shift imaging in multiple sclerosis (MS) lesions has been attributed to iron. However, histopathology studies indicated that iron is a rather rare feature and mainly found in the rim of some lesions. Iron would create non-local distortions of the magnetic field outside susceptibility inclusions. For spheres, the non-local field effect results in a dipole (reduced frequency around the equator of the inclusion and increased frequency in the direction of the magnetic field). We inspected 37 enhancing and 90 non-enhancing nearly spherical lesions. Only 4% of these lesions showed the described feature.

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