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Abstract #0900

Altered magnetic susceptibility in white matter after mild traumatic brain injury

Wei Li 1,2 , Justin Long 1 , Lora Talley Watts 1 , Qiang Shen 1 , and Timothy Q Duong 1,2

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

The white matter damage and its related alterations in brain structural connectivity can be an important factor in determining the neurobehavioral outcomes after traumatic brain injury. This study explored the use of magnetic susceptibility, a novel contrast determined from gradient echo signal phase, for the characterization of white matter changes following mild TBI using a rat model. We found that magnetic susceptibility imaging offers improved sensitivity to white matter changes compared to DTI FA. This study showed the potential of magnetic susceptibility for sensitive detection of white matter damages in vivo.

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