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Abstract #0901

Decreased Magnetic Susceptibility in Mouse Brains with Prenatal Alcohol Exposure

Wei Cao 1,2 , Wei Li 1 , Hui Han 1 , Shonagh K OLeary-Moore 3 , Kathleen K Sulik 3 , G. Allan Johnson 4 , and Chunlei Liu 1,5

1 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2 Tongji Hospital,Huazhong University of Science and Technology, Wuhan, Hubei, China, 3 Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, United States, 4 Center for In Vivo Microscopy, Duke University, Durham, NC, United States, 5 Department of Radiology, Duke University, Durham, NC, United States

Prenatal alcohol exposure can result in the cognitive and behavioral deficits. Quantitative susceptibility mapping (QSM) and DTI was used to assess its impact to deep white matter in mouse brains, respectively. Two groups of mice (n=7, postnatal day 45) were characterized: an ethanol group and a control group. Three main white matter fibers were analyzed. Significantly decreased susceptibility contrast between gray and white matter in ethanol group in each ROI was observed; and there is no significant difference for FA between the two groups. The result indicates the further application of QSM to brain is very promising.

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