Decreased Magnetic Susceptibility in Mouse Brains with Prenatal Alcohol Exposure
Wei Cao 1,2 , Wei Li 1 , Hui Han 1 , Shonagh K OLeary-Moore 3 , Kathleen K Sulik 3 , G. Allan Johnson 4 , and Chunlei Liu 1,5
Brain Imaging and Analysis Center, Duke
University, Durham, NC, United States,
Hospital,Huazhong University of Science and Technology,
Wuhan, Hubei, China,
Center for Alcohol Studies, University of North
Carolina, Chapel Hill, NC, United States,
for In Vivo Microscopy, Duke University, Durham, NC,
of Radiology, Duke University, Durham, NC, United States
Prenatal alcohol exposure can result in the cognitive
and behavioral deficits. Quantitative susceptibility
mapping (QSM) and DTI was used to assess its impact to
deep white matter in mouse brains, respectively. Two
groups of mice (n=7, postnatal day 45) were
characterized: an ethanol group and a control group.
Three main white matter fibers were analyzed.
Significantly decreased susceptibility contrast between
gray and white matter in ethanol group in each ROI was
observed; and there is no significant difference for FA
between the two groups. The result indicates the further
application of QSM to brain is very promising.
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