Quantitative DCE-MRI Assessment of Breast Cancer Response to Neoadjuvant Chemotherapy
Alina Tudorica 1 , Karen Y Oh 1 , Stephen Y-C Chui 1 , Nicole Roy 1 , Megan L Troxell 1 , Yiyi Chen 1 , Arpana Naik 1 , Megan L Holtorf 1 , Aneela Afzal 1 , Zunqiu Chen 1 , Charles S Springer 1 , Xin Li 1 , and Wei Huang 1
Oregon Health & Science University,
Portland, Oregon, United States
Fifteen women with breast cancer underwent DCE-MRI
before, during, and after neoadjuvant chemotherapy.
Pharmacokinetic analysis of DCE-MRI data were performed
using Standard (Tofts) model (SM) and Shutter-Speed
model (SSM). After only one cycle of therapy, % changes
in SM and SSM Ktrans and kep, and SSM-unique Tau_i, as
well as absolute values of Ktrans and kep, provieded
excellent early predictions of pathologic complete
response. Following therapy completion, tumor Tau_i was
inversely, while Ktrans and tumor size were positively,
correlated with residual disease burden. In conclusion,
DCE-MRI functional parameters provided earlier
prediction of response and more accurate assessment of
residual disease compared to tumor size measurement.
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