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Abstract #0952

FUNCTIONAL MAGNETIC RESONANCE IMAGING REVEALS BRAIN CORTEX REMODELING IN A RAT MODEL OF CHRONIC MULTIPLE SCLEROSIS

Stefano Tambalo 1 , Silvia Fiorini 1 , Roberta Rigolio 2 , Pietro Bontempi 1 , Andrea Sbarbati 3 , Guido Cavaletti 2 , Paola Marmiroli 2 , Stefano Pluchino 4 , and Pasquina Marzola 5

1 Dept. of Neuological and Movement Science, Universit di Verona, Verona, Verona, Italy, 2 Dept. of Surgery and Translational Medicine, Universit Milano-Bicocca, Milano, Italy, 3 Dept. of Neuological and Movement Science, INSTM Firenze, Verona, Italy, 4 Dept of Clinical Neurosciences, John Van Geest Centre for Brain Repair, Stem Cell Institute and NIHR, University of Cambridge, Cambridge, United Kingdom, 5 Dept. of Informatics, University of Verona, Verona, Italy

Experimental Autoimmune Encephalomyelitis (EAE) is a good model of Multiple Sclerosis in rodents. We have applied fMRI to invesigate the alteration in functional response in rats induced with EAE. Cortical activation is altered in EAE rat brain, compared to controls. fMRI showed an increase in the activated volume involving also the cortex ipsilateral and some extra-cortical areas at the observed time points. These results demonstrate brain cortex remodeling in EAE, a remakable feature of MS. The present model seems to be a relevant tool in preclinical MS studies.

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