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Abstract #0963

Altered fatty acid profile of periprostatic adipose tissue in prostate cancer patients: an MR spectroscopic study

Palamadai N Venkatasubramanian 1 , George Iordanescu 1 , Kristian Novakovic 2 , Jennifer Doll 3 , Charles Brendler 2 , and Alice M Wyrwicz 1

1 Radiology, NorthShore University HealthSystem, Evanston, IL, United States, 2 Surgery, NorthShore University HealthSystem, Evanston, IL, United States, 3 Biomedical Sciences, University of Wisconsin at Milwaukee, Milwaukee, WI, United States

Using ex vivo MR spectroscopy we detected alterations in the fatty acid composition of periprostatic adipose tissue from obese prostate cancer patients, relative to their subcutaneous adipose tissue. The altered periprostatic adipose composition was found to have predictive potential for a pathological criterion for aggressive prostate cancer, namely, extracapsular extension. Our results suggest that in vivo MR spectroscopy may have potential for developing a noninvasive biomarker for aggressive prostate cancer.

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