Abstract #0976
In vivo investigations of accuracy and precision of fiber orientations in crossing fibers in spherical deconvolution-based HARDI methods
Sjoerd B. Vos 1 , Chantal M.W. Tax 1 , Martijn Froeling 2 , and Alexander Leemans 1
1
Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Radiology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands
Recently, acquisition and processing parameters have
been proposed to optimally describe the angular profile
of diffusion-weighted signal profiles in single-fiber
voxels. We present an overview of how these factors
affect fODF estimation in crossing-fiber voxels in vivo,
investigating both the accuracy and precision of
reconstructed fODF peaks. Higher b-values provide high
levels of precision and accuracy, even for low number of
DWIs (50-100). On the whole, more directions at lower
b-values performed to similar levels of precision.
However, the longer diffusion-weighting pulses for
higher b-values likely cost less scan time than the
increased number of DWIs required at lower b-values.
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