In vivo investigations of accuracy and precision of fiber orientations in crossing fibers in spherical deconvolution-based HARDI methods
Sjoerd B. Vos 1 , Chantal M.W. Tax 1 , Martijn Froeling 2 , and Alexander Leemans 1
Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
of Radiology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands
Recently, acquisition and processing parameters have
been proposed to optimally describe the angular profile
of diffusion-weighted signal profiles in single-fiber
voxels. We present an overview of how these factors
affect fODF estimation in crossing-fiber voxels in vivo,
investigating both the accuracy and precision of
reconstructed fODF peaks. Higher b-values provide high
levels of precision and accuracy, even for low number of
DWIs (50-100). On the whole, more directions at lower
b-values performed to similar levels of precision.
However, the longer diffusion-weighting pulses for
higher b-values likely cost less scan time than the
increased number of DWIs required at lower b-values.
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