Abstract #0988
Hyperpolarized 13 C-acetate for the detection of metabolic response of the heart to a stress protocol
Ulrich Koellisch 1,2 , Concetta V. Gringeri 2,3 , Giaime Rancan 4 , Markus Durst 1,2 , Markus Schwaiger 3 , Marion I. Menzel 2 , Axel Haase 1 , and Rolf F. Schulte 2
1
IMETUM, Technical University Mnchen,
Munich, Germany,
2
GE
Global Research, Munich, Germany,
3
Nuclear
Medicine, Technical University Mnchen, Munich, Germany,
4
Technical
University Mnchen, Munich, Germany
Acetate metabolism plays an important role particularly
in myocardial cells where acetate gets converted to
acetyl-carnitine (ALCAR) via Acetyl-CoA. Hyperpolarized
MRS using [1-13C]acetate offers the possibility to
investigate its conversion to [1-13C]ALCAR, which could
be a marker for changes of myocardial fatty-acid
metabolism. However the low SNR of ALCAR is the
bottleneck of the proposed method. Adresing this problem
a stress protocol using dobutamine was combined with an
optimized spectrospatial pulse sequence in order to
increase the SNR of ALCAR. The results show a
significant increase of the ALCAR to acetate after
dobutamine administration.
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